A wide variety of colloidal silicon dioxide options are available to you, such as grade standard. Wear safety glasses or goggles if eye contact is possible. A graphic model of aerosil pharma colloidal silicon dioxide aggregates. Silicosis is a chronic disease of the lungs that is caused by the inhalation of silica dust over long period of time. Proprietary ingredients indicated as hazardous have been assessed under standards for workplace safety.
S1510, colloidal silicon dioxide, nf, ep spectrum chemical. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Silicon dioxide, synthetic amorphous silica, pyrogenic silica, hydrophobic fumed silica. This product has been classified in accordance with the hazard criteria of the canadian controlled products. This product has been classified in accordance with the hazard criteria of the cpr and the msds contains all of the information required by the cpr. Aerosil and aeroperl pharma colloidal silicon dioxide 3 the optimal glidant and beyond 2. Some health conditions may make you more susceptible to the sideeffects of the drug. Aerosil and aeroperl pharma colloidal silicon dioxide products. Colloidal silicon dioxide daphnia magna tad ec50 48 hours 14 mgl 24 months rat oral 60 mgkgday noael not carcinogenic. Conditions for safe storage, including any incompatibilities. Before using colloidal silicon dioxide, inform your doctor about your current list of medications, over the counter products e. At levasil colloidal silica we contribute to your success with innovations in silica chemistry. In many parts of the world, silica is the major constituent of sand. Silicon dioxide, single crystal substrate, optical grade, 99.
If you experience drowsiness, dizziness, hypotension or a headache as sideeffects when using colloidal silicon dioxide medicine then it may not be safe to drive a vehicle or operate heavy machinery. Colloidal silica suspension allied high tech products, inc. Safety data sheet according to 19072006ec, article 31 trade name. A safety data sheet will be provided with your first delivery and with subsequent revisions. Colloidal silicon dioxide, nf, ep is used both in the food and pharmaceutical industries as a powder flow helper in the production of tablets. Use fullface self contained breathing apparatus, impervious protective clothing. Firstaid measures inhalation remove victim to fresh air and keep at rest in a position comfortable for breathing. Silicon, 99% powder safety data sheet 06262015 en english us sds id. Silica, colloidal anhydrous silicia colloidalis anhydrica aerosil contd. Get medical aid if irritation develops or persists. This material safety data sheet msds applies only to the material as packaged.
You might have seen it on a label or two and wondered what it is exactly. Colloidal silicon dioxide is a submicroscopic fumed silica prepared by the vaporphase hydrolysis of a silicon compound. Chemtrec usa and canada emergency contact number 1. Sigmaaldrich offers a number of silicon dioxide products.
Safety data sheet according to 19072006ec, article 31. Aerosil colloidal silicon dioxide for pharmaceuticals. Colloidal silicon dioxide 112945525 15 designates that a specific chemical identity andor percentage of composition has been withheld as a trade secret. Section 6 accidental release measures procedures of personal precautions.
Silicon dioxide, amorphous gel, 30% in isopropanol safety. Chemtrec usa and canada emergency contact number 1800424. Discover our broad product portfolio and reliable supply. Silica is one of the most complex and most abundant families of materials, existing as a compound of several minerals and as synthetic product. The information in silicon dioxide e551 msds was obtained from current and reliable sources. Levasil colloidal silica a natural part of everyday life. Product is noncombustible hazardous combustion products. The terms hazardous and hazardous materials as used within this sds eu msd should be interpreted as defined by, and accordance with, the osha.
Sigmaaldrich material safety data sheet date printed. D2b this product contains trace amounts of 1, 3 butadiene, a chemical known to the state of california to cause cancer. Preparation and characterization of silicon dioxide. Silicon dioxide cas 7631869 colloidal, highly dispersed emprove essential ph eur,nf,jp,e 551 find msds or sds, a coa, data sheets and more information. Wear selfcontained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Prosolv smcc silicified microcrystalline cellulose jrs pharma. Ingestion of this material can cause effects similar to those seen in clinical use including cholinergic crisis, charactertized by severe nausea, vomiting, salivation, sweating, slow heart rate, low blood pressure, muscles weakness, respiratory depression, syncope and convulsions. This product has been classified in accordance with the hazard criteria of the controlled products regulations and the msds contains all of the information required by those regulations. Silicon dioxide sio2, or silica, is known in nature as sand or quartz. Silicon dioxide is not biodegradable, however the product itself will not affect environment. This product contains amorphous, colloidal or fumed silica. Under our main product brand levasil colloidal silica and with our global network of manufacturing facilities, we provide our professional partners with a reliable supply of high and consistent quality colloidal silica. Pfizer inc believes that the information contained in this material safety data sheet is accurate.
Safety data sheet creation date 15dec2011 revision date 30sep2019 revision number 5 1. Colloidal kaolin 2457 usp bc pharmaceutical colloidal kaolin, usp are used as as internal absorbent, diluent, filler and opacifier in pharmaceutical prepar ations. Colloidal silica polishing suspension safety data sheet. Fine particulate silica dust from quartz rock causes over a longterm progressive lung injury, silicosis.
Learn more on how colloidal silica differs from fumed and other types of silica. S1510, colloidal silicon dioxide, nf, ep table of contents product specification safety data sheet sds manufacturer certification of quality management system qms certification of current good manufacturing practices cgmp product bsetse statement product allergen statement product aflatoxin statement. Product and company identification product identifier. Glasses are a class of materials made from silicon dioxide and other metal oxides.
Be sure to use an approvedcertified respirator or equivalent. Colloidal silicon dioxide 7631869 2315454 not listed ingredient cas number eu einecselincs list eu classification %. Manufacture of aerosil and aeroperl pharma colloidal silicon dioxide 6 2. Colloidal silicon dioxide daphnia magna tad ec50 48 hours 14 mgl 24 months rat. Silicon dioxide of small particle size may cause irritation and adverse health effects on the skin eyes and lungs silicosis. Do not attempt to take action without suitable protective equipment. Ac403731500 casno 7631869 synonyms silicon dioxide, synthetic amorphous silica, pyrogenic fumed amorphous silica recommended use laboratory chemicals. Prosolv smcc, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose mcc and colloidal silicon dioxide csd. Silica is another name for silicon oxides, the most prevalent type being sio2. Silicon dioxide msds, silicon dioxide materials safety. Aerosil and aeroperl pharma colloidal silicon dioxide. Silicon dioxide, chemically preparednot a pbt, vpvb substance as per the criteria of the. In veterinary applications, it functions as a topical and g. Vinyl acetate vapor may react vigorously in contact with silica gel.
Impervious gloves are recommended if skin contact with drug product is possible and for bulk processing operations. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. Incompatible with fluoride, oxygen, difluoride, chlorine trifluoride. Call 310 5168000 all chemicals may pose unknown hazards and should be used with caution. Colloidal silicon dioxide is actually a commonly used filler product. Definition colloidal silicon dioxide is a submicroscopic fumed silica prepared by the vaporphase hydrolysis of a silicon compound. All spectrum chemical nf, ep grade products are manufactured, packaged and stored under current good manufacturing practices cgmp per 21cfr part 211 in fda registered and inspected facilities. Colloidal silica based primary binder for investment casting manufacturer. Silica, hydrophobic colloidal silica hydrophobica colloidalis definition colloidal silicon dioxide partly alkylated for hydrophobation.
Colloidal silicon dioxide dried specimen in the crucible for the test for loss on ignition. Health hazard reactivity spectrum pharmacy products. Special remarks on reactivity special remarks on corrosivity polymerization will not occur. Identification of the substancemixture and of the companyundertaking. Call a poison center or doctorphysician if you feel unwell. Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. Carbon dioxide, dry chemical powder, or appropriate foam.
Silicon dioxide is a natural compound of silicon and oxygen found mostly in sand, silica has three main crystalline varieties. Should the product become dried or misted such that inhalation of the material is possible, standard hygiene practices should be utilized to ensure that exposure to respirable particles is within the regulated limits. About 52% of these are oxide, 17% are electronics chemicals, and 7% are adsorbent. Uses advised against food, drug, pesticide or biocidal. Dust can combine with air to form an explosive mixture. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Appropriate engineering controls engineering measures to reduce exposure.
A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. Silica is another name for the chemical compound composed of silicon and. Search results for colloidal silicon dioxide at sigmaaldrich. Colloidal silicon dioxide 7631869 2315454 titanium dioxide 463677 2366755. Aerosil colloidal silicon dioxide for pharmaceuticals recommended products. Silicon dioxide, amorphous gel, 30% in isopropanol safety data sheet 08142015 en english us sds id. Also known as colloidal silica, this agent finds itself into many food and medicine products. It is widely used in creams and lotions as a suspending agent and opacifier. When ignited at for 2 hours, it contains not less than 99. Colloidal silicon dioxide 7631869 2315454 not listed not listed microcrystalline cellulose 9004346 2326749 not listed not listed additional information. Impervious protective clothing is recommended if skin contact with drug product is possible and for bulk processing operations. Material safety data sheet according to regulation ec no. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication.